Why the study?
To assess whether loss of nicotinamide nucleotide transhydrogenase (Nnt) alone causes a cardiovascular phenotype, given its link to cardiovascular traits in mice and cardiomyopathy in humans.
Does Nnt loss alone cause a cardiovascular phenotype in C57BL/6 mice?
Population
C57BL/6N, C57BL/6J, and C57BL/6J-BAC transgenic mice
Comparison
C57BL/6N vs C57BL/6J vs C57BL/6J-BAC transgenic rescuing NNT expression
Design
Preclinical animal study
Follow-up
3, 12, and 18 mo
Authors
Loading...
Nnt loss does not cause cardiomyopathy in C57BL/6 mice; leaves open Mylk3's role in human dilated cardiomyopathy.
Does Nnt loss alone cause a cardiovascular phenotype in C57BL/6 mice?
The study demonstrates that the cardiomyopathy phenotype observed in C57BL/6N mice is caused by a Mylk3 null mutation, not the Nnt null mutation found in C57BL/6J mice.
Williams et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: