Population
Dictyostelium discoideum cells
Comparison
Expression of a chimerical fusion protein… vs Control cells
Design
Preclinical
Authors
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GFP-actin fusions may confound motility assays; leaves open reliability of prior actin localization data in other systems.
GFP-actin fusion protein acts as a dominant negative in Dictyostelium, inhibiting cytokinesis and locomotion by forming a rigor complex with myosin II.
Aizawa et al. (1997) studied this question.
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