Key result
Higher carotid-femoral pulse wave velocity is linked to lower memory scores via cerebral microvascular damage.
Why the study?
Is the association between aortic stiffness and memory mediated by cerebrovascular remodeling and parenchymal small vessel disease damage in older adults?
Population
1820 older adult participants (60% women) in the Age, Gene/Environment Susceptibility-Reykjavik Study
Design
Cohort
Authors
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Aortic stiffness may impair memory via cerebral microvascular damage in older adults; leaves open causal pathways and intervention targets.
Observational (n=1,820)
Is the association between aortic stiffness and memory mediated by cerebrovascular remodeling and parenchymal small vessel disease damage in older adults?
Effect estimate: standardized β -0.071
p-value: p=0.002
Aortic stiffness is associated with lower memory scores in older adults, an effect that is substantially mediated by cerebral microvascular remodeling and parenchymal damage.
Cooper et al. (2015) conducted an observational in Cognitive decline (n=1,820). Carotid-femoral pulse wave velocity was evaluated on Memory score (standardized β -0.071, p=0.002). Higher carotid-femoral pulse wave velocity was associated with lower memory scores (standardized β -0.071; P=0.002), an effect partially mediated by cerebral microvascular remodeling and damage.
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