January 27, 2011Cardiovascular ResearchOpen Access

The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function

Q: What is the clinical evidence from this study?

Study design: Other. Population: Heart failure. Primary outcome: Ca(2+) handling parameters including cytosolic and intra-sarcoplasmic reticulum [Ca(2+)].

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Key result

Heart failure progression in a canine model was associated with destabilized RyR2 activity due to excessive CaMKII phosphorylation and oxidation, driving arrhythmogenesis and contractile dysfunction.

Authors

ABAndriy E. BelevychThe Ohio State University Wexner Medical Center DTDmitry TerentyevNew Jersey Institute of Technology RTRadmila TerentyevaThe Ohio State University Wexner Medical Center

Discussion

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Implication

Should not yet change HF practice; hypothesis-generating for CaMKII-RyR2 targeting in translational models.

PICO

Population

Heart failure

Primary Outcome

Ca(2+) handling parameters including cytosolic and intra-sarcoplasmic reticulum [Ca(2+)]

Cite This Study

Belevych et al. (2011) studied Heart failure. Heart failure progression in a canine model was associated with destabilized RyR2 activity due to excessive CaMKII phosphorylation and oxidation, driving arrhythmogenesis and contractile dysfunction.

synapsesocial.com/papers/6a0931814c1e2db30bd263bd https://doi.org/10.1093/cvr/cvr025

Topics

Heart failure HFrEF treatment

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The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function

Discussion

Member takes

Implication

PICO

Cite This Study

Topics

The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function

Discussion

Member takes

Implication

PICO

Cite This Study

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