Key result
Adult rat ventricular myocytes undergo profound morphological and functional changes over 5 days in culture, including reduced cell area, T-tubule density, and membrane currents, independent of apoptosis.
Population
Adult rat ventricular myocytes in primary culture
Comparison
Long-term cell culture (5 days) vs Baseline (day 0)
Design
Preclinical
Follow-up
5 days
Authors
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Caution required when modeling with long-term cultured rat myocytes; leaves open optimal culture conditions for preserving native properties.
Adult rat ventricular myocytes undergo profound morphological and electrophysiological adaptations during long-term primary culture that are not due to apoptosis or necrosis.
Bányász et al. (2007) studied Adult rat cardiac myocytes in primary culture. Long-term cell culture vs. Baseline (day 0) was evaluated on Morphological, electrical and mechanical alterations. Adult rat ventricular myocytes undergo profound morphological and functional changes over 5 days in culture, including reduced cell area, T-tubule density, and membrane currents, independent of apoptosis.
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