Key result
Highest Dietary Inflammatory Index quartile in women links to ~37% higher severe depression risk.
Why the study?
Systemic inflammation may contribute to the etiology of depression and anxiety, but the association between dietary inflammatory potential and these conditions needed investigation.
Does a higher Dietary Inflammatory Index (DII) score increase the risk of depression and anxiety in adults aged 35-65 years?
Cross-Sectional (n=7,083)
No
Does a higher Dietary Inflammatory Index (DII) score increase the risk of depression and anxiety in adults aged 35-65 years?
Effect estimate: OR 1.37 (95% CI 1.03-1.83)
p-value: p=0.032
A pro-inflammatory diet, as measured by a higher Dietary Inflammatory Index score, is associated with an increased risk of severe depression in women, but not in men, within this Iranian cohort.
No practice change from cross-sectional data in women; leaves open causal confirmation in prospective studies.
BACKGROUND: Systemic inflammation is emerging as an important factor in the etiology of psychiatric disorders such as depression and anxiety. Therefore, the inflammatory potential of the diet may also be an etiological factor for these conditions, and this may be estimated by calculating the dietary inflammatory index (DII®) score. We aimed to investigate the association between DII score and incidence of depression and anxiety among a representative sample in northeastern Iran. METHODS: This cross-sectional study undertook in a sub-sample of 7083 adults aged 35 to 65 years recruited as part of Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort study population, and after excluding subjects with incomplete data. All participants completed the Beck Anxiety Inventory (BAI), the Beck Depression Inventory II (BDI-II), and a validated 65-item food frequency questionnaire (FFQ). Logistic regression was used to evaluate the association between DII score and depression/anxiety score. RESULTS: Of the study participants, 37.1% (n = 2631) were found to have mild to severe depression, and 50.5% (n = 3580) were affected by mild to severe anxiety. After adjusting for confounding factors, in women, the third (OR: 1.41, 95% CI: 1.06-1.88, p-values< 0.05) and fourth quartiles (OR: 1.37, 95% CI: 1.03-1.83, p-values< 0.05) of DII score were associated with increased risk of a high depression score compared to the first quartile of DII score. CONCLUSION: There was a significant association between DII score and severe depression among women but not men in this Iranian population. In order to confirm the association between DII food score, depression, and anxiety, further research is required in different populations, and perhaps an intervention study.
No takes yet. Share an insight, caveat, or question.
Ghazizadeh et al. (2020) conducted a cross-sectional in Depression and anxiety (n=7,083). Dietary Inflammatory Index (DII) score (Quartile 4) vs. Dietary Inflammatory Index (DII) score (Quartile 1) was evaluated on Severe depression in women (OR 1.37, 95% CI 1.03-1.83, p=0.032). In women, the highest quartile of the Dietary Inflammatory Index score was associated with a significantly increased risk of severe depression compared to the lowest quartile (OR 1.37).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: