December 7, 2012PLoS ONEOpen Access

Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations

View Full Paper

Ask AI

Bookmark

Population

9,813 individuals in the discovery phase, plus 7,000 African Americans in the replication phase

Design

Meta-analysis

Authors

CEClara C. ElbersAmsterdam Neuroscience YGYiran GuoShanghai Jiao Tong University VTVinicius TragantePreventive Cardiology

Discussion

Member takes

Implication

May refine lipid polygenic scores in diverse groups; extends GWAS loci beyond European cohorts.

Structured PICO

Population

9,813 individuals (7,657 African Americans, 1,315 Hispanics, 841 East Asians) in the discovery phase, plus 7,000 African Americans in the replication phase

Intervention

Dense genotyping of ~2,000 candidate genes using the IBC array

Outcome

Genetic associations with lipid levels (total cholesterol, LDL-C, HDL-C)surrogate

Dense genotyping in diverse populations identified novel genetic loci (ICAM1 and CD36) associated with lipid traits, highlighting the value of multi-ethnic cohorts in genetic discovery.

Cite This Study

Elbers et al. (2012) studied this question.

synapsesocial.com/papers/6a09331a1d1abd907d16121f https://doi.org/10.1371/journal.pone.0050198

View Full Paper

Ask AI

Bookmark

December 7, 2012PLoS ONEOpen Access

Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations

View Full Paper

Ask AI

Bookmark

Population

9,813 individuals in the discovery phase, plus 7,000 African Americans in the replication phase

Design

Meta-analysis

Authors

CEClara C. ElbersAmsterdam Neuroscience YGYiran GuoShanghai Jiao Tong University VTVinicius TragantePreventive Cardiology

Discussion

Member takes

Implication

May refine lipid polygenic scores in diverse groups; extends GWAS loci beyond European cohorts.

Structured PICO

Population

9,813 individuals (7,657 African Americans, 1,315 Hispanics, 841 East Asians) in the discovery phase, plus 7,000 African Americans in the replication phase

Intervention

Dense genotyping of ~2,000 candidate genes using the IBC array

Outcome

Genetic associations with lipid levels (total cholesterol, LDL-C, HDL-C)surrogate

Dense genotyping in diverse populations identified novel genetic loci (ICAM1 and CD36) associated with lipid traits, highlighting the value of multi-ethnic cohorts in genetic discovery.

Cite This Study

Elbers et al. (2012) studied this question.

synapsesocial.com/papers/6a09331a1d1abd907d16121f https://doi.org/10.1371/journal.pone.0050198

View Full Paper

Ask AI

Bookmark