What is the clinical evidence from this study?

Study design: Meta-Analysis. Population: Dyslipidemia (n=12259). Intervention: Genetic variants (SNPs) vs. Reference alleles. Primary outcome: Genome-wide significant associations with lipid traits (total cholesterol, HDL, LDL, triglycerides) (p=<5x10^-8).

What does this research mean for the field?

Genome-wide meta-analysis in Hispanic individuals identifies novel genetic loci and population-specific independent variants associated with lipid traits, with top loci showing tissue-specific eQTL enrichment. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 19, 2016Scientific ReportsOpen Access

Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects and tissue-specific enrichment of eQTLs

Q: What are the key findings of this study?

A genome-wide meta-analysis in 12,259 Hispanic individuals identified novel loci and population-specific effects for lipid traits, including genome-wide significant signals in CELSR2, ZNF259/APOA5, KANK2/DOCK6, and NCAN/MAU2.

Q: What does this research mean for the field?

Genome-wide meta-analysis in Hispanic individuals identifies novel genetic loci and population-specific independent variants associated with lipid traits, with top loci showing tissue-specific eQTL enrichment. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

GWAS meta-analysis identifies novel loci and population-specific effects for lipid traits in Hispanic individuals.

P<5x10^-8
n=12,259

Population

12,259 individuals of Mexican and Mexican American ancestry

Design

Meta-analysis

Authors

JBJennifer E. Below EPEsteban J. Parra EGEric R. Gamazon

Discussion

Member takes

Overview

May inform ancestry-specific lipid PRS in Hispanics; extends European-centric GWAS but leaves clinical translation open.

Study Design

Type

Meta-Analysis (n=12,259)

Multicenter

Yes

Structured PICO

Population

12,259 individuals of Hispanic and Mexican ancestry included in a genome-wide meta-analysis to identify genetic loci associated with plasma lipid traits.

Outcome

Genetic loci associated with total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceridessurrogate

Main Result

p-value: p=<5x10^-8

This genome-wide meta-analysis identifies novel genetic loci associated with lipid traits in Hispanic populations, highlighting population-specific effects and tissue-specific eQTL enrichment.

Limitations

Discovery cohorts were originally ascertained for type 2 diabetes GWAS, resulting in an enrichment of type 2 diabetes patients.
Sample size is relatively small compared to large-scale European GWAS efforts.
Potential confounding by lipid-lowering medications, although statistical adjustments and exclusions were applied.

Cite This Study

Below et al. (2016) conducted a meta-analysis in Dyslipidemia (n=12,259). Genetic variants (SNPs) vs. Reference alleles was evaluated on Genome-wide significant associations with lipid traits (total cholesterol, HDL, LDL, triglycerides) (p=<5x10^-8). A genome-wide meta-analysis in 12,259 Hispanic individuals identified novel loci and population-specific effects for lipid traits, including genome-wide significant signals in CELSR2, ZNF259/APOA5, KANK2/DOCK6, and NCAN/MAU2.

synapsesocial.com/papers/6aa631820ab0fd924bf4ce2b https://doi.org/10.1038/srep19429

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January 19, 2016Scientific ReportsOpen Access

Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects and tissue-specific enrichment of eQTLs

View Full Paper

Ask AI

Bookmark

Key result

GWAS meta-analysis identifies novel loci and population-specific effects for lipid traits in Hispanic individuals.

P<5x10^-8
n=12,259

Population

12,259 individuals of Mexican and Mexican American ancestry

Design

Meta-analysis

Authors

JBJennifer E. Below EPEsteban J. Parra EGEric R. Gamazon

Discussion

Member takes

Overview

May inform ancestry-specific lipid PRS in Hispanics; extends European-centric GWAS but leaves clinical translation open.

Study Design

Type

Meta-Analysis (n=12,259)

Multicenter

Yes

Structured PICO

Population

12,259 individuals of Hispanic and Mexican ancestry included in a genome-wide meta-analysis to identify genetic loci associated with plasma lipid traits.

Outcome

Genetic loci associated with total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceridessurrogate

Main Result

p-value: p=<5x10^-8

This genome-wide meta-analysis identifies novel genetic loci associated with lipid traits in Hispanic populations, highlighting population-specific effects and tissue-specific eQTL enrichment.

Limitations

Discovery cohorts were originally ascertained for type 2 diabetes GWAS, resulting in an enrichment of type 2 diabetes patients.
Sample size is relatively small compared to large-scale European GWAS efforts.
Potential confounding by lipid-lowering medications, although statistical adjustments and exclusions were applied.

Cite This Study

synapsesocial.com/papers/6aa631820ab0fd924bf4ce2b https://doi.org/10.1038/srep19429

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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