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December 12, 2009Circulation Cardiovascular GeneticsOpen Access

5 SNPs were significant after Bonferroni correction (P=2.20 x 10(-3) to 2.6 x 10(-11)), with the strongest signal for triglycerides with the minor allele of rs964184 (P=2.6 x 10(-11), OR 1.74).

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Population

2,298 Mexican individuals from familial combined hyperlipidemia families and hypertriglyceridemia…

Design

Case-control

Authors

DWDaphna Weissglas‐VolkovCACarlos A. Aguilar‐SalinasJSJanet S. Sinsheimer

Discussion

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Overview

Replicates lipid GWAS loci in Mexicans; hypothesis-generating for ancestry-specific dyslipidemia risk without altering practice.

Structured PICO

P
Population
2,298 Mexican individuals from familial combined hyperlipidemia families and hypertriglyceridemia case-control study samples
I
Intervention
14 single-nucleotide polymorphisms (6 for triglycerides, 7 for HDL-C, 1 for both) identified in Caucasian genome-wide association studies
O
Outcome
Association with plasma high-density lipoprotein cholesterol and triglycerides levelssurrogate

Replication of 5 Caucasian GWAS lipid-associated loci in a Mexican population, highlighting a high frequency of the rs964184 risk allele which may contribute to dyslipidemia predisposition.

Cite This Study

Weissglas‐Volkov et al. (2009) studied this question.

synapsesocial.com/papers/6a7170ea6c240de38cdc240ahttps://doi.org/10.1161/circgenetics.109.908004
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