July 3, 2014PLoS ONEOpen Access

Common genetic variants at APOA1, CETP, CELSR2-PSRC1-SORT1, and TRIB1 were significantly associated with altered lipid traits in the Indian population, with urban location and sex showing strong interaction effects.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Dyslipidemia / Lipid Traits (n=3342). Intervention: Common genetic variants (rs964184 at APOA1, rs3764261 at CETP, rs646776 at CELSR2-PSRC1-SORT1, rs2954029 at TRIB1) vs. Non-risk alleles. Primary outcome: Change in triglycerides per copy of the risk allele of rs964184 at APOA1 (1.06 mmol/l increase, p=0.006).

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Why the study?

Are common genetic variants associated with altered plasma lipid levels in the Indian population?

Population

1,671 sib pairs from the Indian Migration Study, comprising migrant and non-migrant factory workers and…

Design

Cross-sectional

Key result

Common genetic variants at APOA1, CETP, CELSR2-PSRC1-SORT1, and TRIB1 were significantly associated with altered lipid traits in the Indian population, with urban location and sex showing strong interaction effects.

Authors

GWGagandeep Kaur Walia VGVipin Gupta AAAastha Aggarwal

Discussion

Member takes

Overview

May refine ancestry-specific lipid risk models in Indians; leaves open prospective validation of urbanization-sex interactions before clinical use.

Study Design

Type

Observational (n=3,342)

Multicenter

Yes

Structured PICO

Are common genetic variants associated with altered plasma lipid levels in the Indian population?

Population

3,342 individuals (1,671 sib pairs) from the Indian Migration Study, including factory workers and their rural siblings, assessed for genetic associations with lipid traits.

Exposure

Six single nucleotide polymorphisms (SNPs) related to cardiometabolic traits (rs964184 at APOA1, rs3764261 at CETP, rs646776 at CELSR2-PSRC1-SORT1, rs1412444 at LIPA, rs974819 at PDGFD, rs2954029 at TRIB1)

Outcome

Four lipid traits: total cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C)surrogate

Main Result

Mean Difference: 1.06

p-value: p=0.006

This study validates four genetic variants associated with lipid traits in the Indian population, demonstrating that urbanization and sex influence these genetic associations.

Limitations

Findings will require replication in other Indian populations.
Stratified analysis by location, fat intake, and physical activity could not be performed due to limited sample size in these groups.
Correction for multiple testing was not applied for lipid traits as the studied SNPs are established loci.
Findings will require replication in other Indian populations
Stratified analysis by location, fat intake and physical activity could not be performed due to limited sample size

Cite This Study

Walia et al. (2014) conducted an observational in Dyslipidemia / Lipid Traits (n=3,342). Common genetic variants (rs964184 at APOA1, rs3764261 at CETP, rs646776 at CELSR2-PSRC1-SORT1, rs2954029 at TRIB1) vs. Non-risk alleles was evaluated on Change in triglycerides per copy of the risk allele of rs964184 at APOA1 (1.06 mmol/l increase, p=0.006). Common genetic variants at APOA1, CETP, CELSR2-PSRC1-SORT1, and TRIB1 were significantly associated with altered lipid traits in the Indian population, with urban location and sex showing strong interaction effects.

synapsesocial.com/papers/6a94fbf31fe04514d10f35c2 https://doi.org/10.1371/journal.pone.0101688

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July 3, 2014PLoS ONEOpen Access

Common genetic variants at APOA1, CETP, CELSR2-PSRC1-SORT1, and TRIB1 were significantly associated with altered lipid traits in the Indian population, with urban location and sex showing strong interaction effects.

View Full Paper

Ask AI

Bookmark

Why the study?

Are common genetic variants associated with altered plasma lipid levels in the Indian population?

Population

1,671 sib pairs from the Indian Migration Study, comprising migrant and non-migrant factory workers and…

Design

Cross-sectional

Key result

Authors

GWGagandeep Kaur Walia VGVipin Gupta AAAastha Aggarwal

Discussion

Member takes

Overview

May refine ancestry-specific lipid risk models in Indians; leaves open prospective validation of urbanization-sex interactions before clinical use.

Study Design

Type

Observational (n=3,342)

Multicenter

Yes

Structured PICO

Are common genetic variants associated with altered plasma lipid levels in the Indian population?

Population

3,342 individuals (1,671 sib pairs) from the Indian Migration Study, including factory workers and their rural siblings, assessed for genetic associations with lipid traits.

Exposure

Outcome

Four lipid traits: total cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C)surrogate

Main Result

Mean Difference: 1.06

p-value: p=0.006

This study validates four genetic variants associated with lipid traits in the Indian population, demonstrating that urbanization and sex influence these genetic associations.

Limitations

Findings will require replication in other Indian populations.
Stratified analysis by location, fat intake, and physical activity could not be performed due to limited sample size in these groups.
Correction for multiple testing was not applied for lipid traits as the studied SNPs are established loci.
Findings will require replication in other Indian populations
Stratified analysis by location, fat intake and physical activity could not be performed due to limited sample size

Cite This Study

synapsesocial.com/papers/6a94fbf31fe04514d10f35c2 https://doi.org/10.1371/journal.pone.0101688

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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