Key result
A combined gene score of four common variants in triglyceride and HDL-C metabolism genes significantly altered lipid levels but was not associated with increased coronary artery disease risk (OR 1.09, 95% CI 0.92-1.3).
Why the study?
Do common variants in triglyceride and HDL-C metabolism genes increase the risk of coronary artery disease in a Pakistani population?
Population
640 subjects from Punjab, Pakistan.
Comparison
Presence of risk alleles in four single… vs Absence of risk alleles / healthy controls
Design
Case-control
Authors
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Variants altering TG/HDL-C levels show no CAD association here; leaves open causal effects in other populations.
Case-Control (n=640)
Yes
Do common variants in triglyceride and HDL-C metabolism genes increase the risk of coronary artery disease in a Pakistani population?
Odds Ratio: 1.09 (95% CI 0.92–1.3)
p-value: p=0.32
Common variants in lipid metabolism genes (LPL, APOA5, CETP) significantly affect serum triglyceride and HDL-C levels but do not show a statistically significant association with coronary artery disease risk in this Pakistani cohort.
Shahid et al. (2017) conducted a case-control in Coronary artery disease (n=640). Common variants in LPL, APOA5, and CETP genes vs. Healthy controls was evaluated on Coronary artery disease risk (combined gene score) (OR 1.09, 95% CI 0.92-1.3, p=0.32). A combined gene score of four common variants in triglyceride and HDL-C metabolism genes significantly altered lipid levels but was not associated with increased coronary artery disease risk (OR 1.09, 95% CI 0.92-1.3).
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