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January 1, 2005Journal of Atherosclerosis and ThrombosisOpen Access

Polymorphisms in Four Genes Related to Triglyceride and HDL-cholesterol Levels in the General Japanese Population in 2000

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Why the study?

Are common polymorphisms in CETP, LPL, LIPC, and APOC3 genes associated with serum lipid levels in the general Japanese population?

Population

2267 individuals randomly selected from the participants of Serum Lipid Survey 2000 in the general Japanese…

Design

Cross-sectional

Authors

HAHidenori AraiAYAkira YamamotoYMYūji Matsuzawa

Discussion

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Overview

May refine genetic insights into dyslipidemia among Japanese adults; leaves open effects on cardiovascular outcomes or therapy.

Structured PICO

Are common polymorphisms in CETP, LPL, LIPC, and APOC3 genes associated with serum lipid levels in the general Japanese population?

P
Population
2267 individuals randomly selected from the participants of Serum Lipid Survey 2000 in the general Japanese population
I
Intervention
Six common single-nucleotide polymorphisms (SNPs) in four genes related to lipid metabolism (CETP, LPL, LIPC, and APOC3)
O
Outcome
Serum lipid levels (HDL-cholesterol and triglyceride levels)surrogate

Common genetic variants in CETP, LPL, LIPC, and APOC3 are significantly associated with HDL-cholesterol and triglyceride levels in the Japanese population.

Limitations

  • Further study is necessary to elucidate the role of these gene polymorphisms in cardiovascular events

Cite This Study

Arai et al. (2005) studied this question.

synapsesocial.com/papers/6a82c0c50f52607ca18ae53chttps://doi.org/10.5551/jat.12.240
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of the C−514T Polymorphism in the Hepatic Lipase Gene With Variations in Lipoprotein Subclass Profiles2000 · 106 citations
  2. 2Increased risk for endogenous hypertriglyceridaemia is associated with an apolipoprotein C3 haplotype specified by the <i>Sst</i>I polymorphism1998 · 40 citations
  3. 3DNA variants at the LPL gene locus associate with angiographically defined severity of atherosclerosis and serum lipoprotein levels in a Welsh population.1994 · 140 citations
  4. 4Apolipoprotein C3 SstI polymorphism and triglyceride levels in Asian Indians2002 · 38 citations
  5. 5Lack of association of the apolipoprotein A-I-C-III-A-IV gene XmnI and SstI polymorphisms and of the lipoprotein lipase gene mutations in familial combined hyperlipoproteinemia in French Canadian subjects1996 · 40 citations