Why the study?
Are genetic variations in the LPL gene associated with hypoalphalipoproteinemia and elevated triglycerides in Japanese schoolchildren?
Population
308 Japanese schoolchildren, comprising 114 with low HDL-C levels (<40 mg/dl) and 194 control children.
Comparison
Assessment of LPL gene polymorphisms and… vs Control children without low HDL-C
Design
Case-control
Authors
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Supports targeted LPL studies in Japanese pediatric dyslipidemia; hypothesis-generating and should not yet change practice.
Are genetic variations in the LPL gene associated with hypoalphalipoproteinemia and elevated triglycerides in Japanese schoolchildren?
Genetic variations in the LPL gene, particularly the Pvu II polymorphism, are associated with hypoalphalipoproteinemia and elevated triglycerides in Japanese schoolchildren.
Yamana et al. (1998) studied this question.
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