Why the study?
Are genetic loci associated with lipid concentrations in Europeans also associated with plasma lipid profiles in a Japanese population?
Population
21,010 Japanese individuals
Design
Cross-sectional
Key result
In 21,010 Japanese individuals, rs3812316 in MLXIPL was associated with a 7.1 mg/dl decrease in triglycerides per minor C allele (p~3.0x10^-11), and rs599839 was associated with lower LDL cholesterol.
Authors
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Replicates European lipid loci in Japanese adults; extends trans-ancestry evidence but leaves clinical risk stratification open.
Observational (n=21,010)
Are genetic loci associated with lipid concentrations in Europeans also associated with plasma lipid profiles in a Japanese population?
Mean Difference: -7.1
p-value: p=3.0x10(-11)
Genetic associations between novel loci and plasma lipid concentrations discovered in Europeans are generally conserved in the Japanese population, with some exceptions likely due to ethnic differences in linkage disequilibrium.
Nakayama et al. (2009) conducted an observational in Plasma lipid profiles (n=21,010). SNPs within seven novel loci was evaluated on Triglyceride concentrations (7.1 mg/dl decrease per minor C allele, p=3.0x10(-11)). In 21,010 Japanese individuals, rs3812316 in MLXIPL was associated with a 7.1 mg/dl decrease in triglycerides per minor C allele (p~3.0x10^-11), and rs599839 was associated with lower LDL cholesterol.
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