Why the study?
Do genetic variants associated with lipid traits in Europeans also affect lipid parameters in a Chinese Han population?
Population
4,192 individuals from a Chinese Han population
Design
Cross-sectional
Key result
Ten SNPs in nine loci were significantly associated with lipid traits and dyslipidemia in a Chinese Han population, with the strongest association between rs3764261 and HDL-C (P ~ 4.3 × 10(-14)).
Authors
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Extends lipid GWAS loci to Chinese Han; leaves open replication and clinical translation for dyslipidemia risk.
Cross-Sectional (n=4,192)
Do genetic variants associated with lipid traits in Europeans also affect lipid parameters in a Chinese Han population?
Genetic loci associated with lipid traits in European populations exert similar effects on lipid and lipoprotein concentrations in a Chinese Han population.
Liu et al. (2010) conducted a cross-sectional in Dyslipidemia (n=4,192). 10 single-nucleotide polymorphisms (SNPs) in nine loci was evaluated on Plasma lipid and lipoprotein concentrations (total cholesterol, triglycerides, HDL-C, LDL-C, and total cholesterol-HDL-C-related ratio). Ten SNPs in nine loci were significantly associated with lipid traits and dyslipidemia in a Chinese Han population, with the strongest association between rs3764261 and HDL-C (P ~ 4.3 × 10(-14)).