Key result
The C allele of the rs4758685 polymorphism in the MLXIP gene was significantly associated with a reduced risk of coronary heart disease (OR 0.83) in the Chinese Han population.
Why the study?
Are specific metabolic-related candidate gene polymorphisms associated with coronary heart disease in the Chinese Han population?
Case-Control (n=1,172)
Yes
Are specific metabolic-related candidate gene polymorphisms associated with coronary heart disease in the Chinese Han population?
Odds Ratio: 0.83 (95% CI 0.71–0.98)
p-value: p=0.02
The rs4758685 polymorphism in the MLXIP gene is a novel genetic variant associated with a protective effect against coronary heart disease in the Chinese Han population.
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rs4758685 C allele associated with lower CHD risk in Chinese Han; hypothesis-generating and requires replication before clinical consideration.
Alobeidy et al. (2013) conducted a case-control in Coronary Heart Disease (n=1,172). rs4758685 polymorphism in MLXIP gene (C allele) vs. T allele / non-carriers was evaluated on Association with Coronary Heart Disease (OR 0.83, 95% CI 0.71-0.98, p=0.02). The C allele of the rs4758685 polymorphism in the MLXIP gene was significantly associated with a reduced risk of coronary heart disease (OR 0.83) in the Chinese Han population.
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