Lack of Association of LPA Gene Polymorphisms with Coronary Artery Disease in Pakistani Subjects
Why the study?
Pakistan faces an increasing epidemic of CAD, and the lipoprotein A gene has been associated with CAD, prompting investigation of LPA gene SNPs in this population.
Do LPA gene SNPs rs3798220 and rs10455872 associate with coronary artery disease in Pakistani subjects?
Population
Pakistani subjects with CAD and controls
Comparison
LPA gene SNPs rs3798220 and rs10455872 in cases vs controls
Design
Case-control study
Authors
Discussion
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Member takes
Implication
Null LPA associations do not support genotyping for CAD risk in Pakistanis; leaves open population-specific effects pending larger studies.
Structured PICO
Do LPA gene SNPs rs3798220 and rs10455872 associate with coronary artery disease in Pakistani subjects?
P
Population
Pakistani subjects with coronary artery disease (CAD)
I
Intervention
LPA gene SNPs rs3798220 and rs10455872
C
Comparator
Pakistani subjects without CAD (controls)
O
Outcome
Association with coronary artery diseasesurrogate
LPA gene SNPs rs3798220 and rs10455872 are not significantly associated with coronary artery disease in the Pakistani population.
Cite This Study
Shahid et al. (2021) studied this question.