Key result
A weighted genetic risk score based on five variants was associated with a 36.31 mg/dL increase in triglyceride and VLDL-C levels among North Indian participants.
Why the study?
Are 12 specific genetic variants associated with lipid levels in the Indian population?
Population
2,117 rural and urban Indian participants
Design
Cross-sectional
Authors
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Genetic risk score links to higher triglycerides in Indians; extends GWAS loci to South Asian ancestry but leaves clinical utility open pending prospective data.
Cross-Sectional (n=2,117)
Yes
Are 12 specific genetic variants associated with lipid levels in the Indian population?
Effect estimate: β = 0.95
p-value: p=<0.001
The study validates the role of eight GWAS loci related to lipid levels in the Indian population and demonstrates their combined effect using polygenic risk scores.
Walia et al. (2024) conducted a cross-sectional in Dyslipidemia (n=2,117). Weighted genetic risk score (wGRS) for lipid levels vs. Lower genetic risk score was evaluated on Triglyceride and VLDL-C levels (β = 0.95, p=<0.001). A weighted genetic risk score based on five variants was associated with a 36.31 mg/dL increase in triglyceride and VLDL-C levels among North Indian participants.
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