Why the study?
Does variation in Lmf1 expression modulate LPL activity in vivo?
Population
aP2-Lmf1 and Mck-Lmf1 transgenic mice, and a human dyslipidemic cohort
Design
Preclinical
Authors
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No immediate change to dyslipidemia care; leaves open LMF1 as a therapeutic target pending clinical validation.
Does variation in Lmf1 expression modulate LPL activity in vivo?
Variation in Lmf1 expression is a posttranslational determinant of LPL activity, highlighting its role in lipid metabolism.
Hosseini et al. (2012) studied this question.
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