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August 1, 1993Journal of Biological ChemistryOpen Access

Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia.

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Why the study?

Does overexpression of human lipoprotein lipase prevent diet-induced hypertriglyceridemia and hypercholesterolemia in transgenic mice?

Population

Transgenic mice overexpressing the human lipoprotein lipase gene and control mice

Comparison

Overexpression of human lipoprotein lipase gene vs Control mice

Design

Preclinical

Authors

MSMasako ShimadaHSHitoshi ShimanoTGTakanari Gotoda

Discussion

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Overview

Does not support clinical translation; leaves open LPL overexpression as a therapeutic hypothesis in human hyperlipidemia.

Structured PICO

Does overexpression of human lipoprotein lipase prevent diet-induced hypertriglyceridemia and hypercholesterolemia in transgenic mice?

P
Population
Transgenic mice overexpressing the human lipoprotein lipase (LPL) gene (highest expressor line) and control mice
I
Intervention
Overexpression of human lipoprotein lipase (LPL) gene
C
Comparator
Control mice
O
Outcome
Plasma triglyceride and cholesterol levels, and clearance of triglyceride-rich lipoproteinssurrogate

Overexpression of human lipoprotein lipase in transgenic mice protects against diet-induced hypertriglyceridemia and hypercholesterolemia by enhancing lipolytic conversion and clearance.

Cite This Study

Shimada et al. (1993) studied this question.

synapsesocial.com/papers/6a7d73580ae9e6500d83e702https://doi.org/10.1016/s0021-9258(17)46793-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Amino acid substitution (Ile194----Thr) in exon 5 of the lipoprotein lipase gene causes lipoprotein lipase deficiency in three unrelated probands. Support for a multicentric origin.1991 · 73 citations
  2. 2Metabolism of endothelial cell-bound lipoprotein lipase. Evidence for heparan sulfate proteoglycan-mediated internalization and recycling.1990 · 92 citations
  3. 3Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil.1987 · 263 citations
  4. 4Lipoprotein lipaseBethesda: a single amino acid substitution (Ala-176----Thr) leads to abnormal heparin binding and loss of enzymic activity.1990 · 77 citations
  5. 5Plasma triglyceride and coronary heart disease.1991 · 703 citations