July 1, 1994Journal of Biological ChemistryOpen Access

Transgenic mice expressing human lipoprotein lipase driven by the mouse metallothionein promoter. A phenotype associated with increased perinatal mortality and reduced plasma very low density lipoprotein of normal size.

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Why the study?

Does transgenic overexpression of human lipoprotein lipase alter VLDL metabolism and perinatal survival in mice?

Population

Transgenic mice expressing human lipoprotein lipase (LPL) driven by the mouse metallothionein I promoter

Comparison

Transgenic overexpression of human lipoprotein… vs Control animals (non-transgenic mice)

Design

Preclinical

Authors

EZElőd János ZsigmondSemmelweis University ESE. SchefflerBoehringer Ingelheim (Germany)TFTrudy M. ForteRutgers, The State University of New Jersey

Discussion

Member takes

Implication

May inform LPL-targeted triglyceride therapies; leaves open perinatal safety and human translation from mouse models.

Structured PICO

Does transgenic overexpression of human lipoprotein lipase alter VLDL metabolism and perinatal survival in mice?

Population

Transgenic mice expressing human lipoprotein lipase (LPL) driven by the mouse metallothionein I promoter

Intervention

Transgenic overexpression of human lipoprotein lipase (LPL)

Comparator

Control animals (non-transgenic mice)

Outcome

Perinatal mortality and plasma very low density lipoprotein (VLDL) levelssurrogate

Overexpression of human LPL in transgenic mice significantly reduces plasma VLDL and abolishes diet-induced hypertriglyceridemia, though it causes high perinatal mortality that is preventable by maternal high-fat diet.

Cite This Study

Zsigmond et al. (1994) studied this question.

synapsesocial.com/papers/6a77bb3c6c53f758bc1ea589 https://doi.org/10.1016/s0021-9258(17)32233-0

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Transgenic mice expressing human lipoprotein lipase driven by the mouse metallothionein promoter. A phenotype associated with increased perinatal mortality and reduced plasma very low density lipoprotein of normal size.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Transgenic mice expressing human lipoprotein lipase driven by the mouse metallothionein promoter. A phenotype associated with increased perinatal mortality and reduced plasma very low density lipoprotein of normal size.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider