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Measures formation rates and thermal stabilities of RNA:DNA hybrids and DNA:DNA duplexes in high formamide concentrations, indicating distinct behavior.
The thermal stabilities of RNA:DNA hybrids are substantially greater than those of DNA:DNA duplexes in aqueous electrolyte solutions containing high concentrations of formamide. Association rates to form DNA:DNA duplexes and DNA:RNA hybrids have been measured in these solvents. There is a temperature range in which DNA:DNA rates are negligible and RNA:DNA rates close to optimal.
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Casey et al. (1977) studied this question.
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