Why the study?
The study was conducted to provide a critical assessment of the obesity paradox and highlight methodological errors in existing studies investigating this phenomenon.
Does overweight and obesity improve survival in patients with cardiovascular diseases compared to normal weight?
Does overweight and obesity improve survival in patients with cardiovascular diseases compared to normal weight?
The obesity paradox in cardiovascular disease is likely an artifact of methodological flaws, such as reverse causality and confounding by smoking, requiring a reconsideration of the phenomenon.
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Questions obesity as protective in CVD; leaves open true associations pending rigorous, bias-adjusted studies.
The article gives a critical assessment of the so-called obesity paradox. Methodological errors that occur in the organization of studies that studied the obesity paradox and the formation of comparison groups are highlighted. There are also examples of the disappearance of the obesity paradox when taking into account additional risk factors. The organization of prospective studies or more careful consideration of all currently known risk factors for cardiovascular diseases (CVD) will significantly improve the results of the study of the effect of overweight and obesity on mortality in patients with CVD. Thus, despite the biological possibility of the existence of a positive effect of adipose tissue in CVD, the presence of a large number of errors identified in the analysis of the work of researchers obesity paradox require to reconsider the existence of this phenomenon, it should be taken into account the possibility that the obesity paradox may be a consequence of improper design studies to investigate this phenomenon.
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Miklisanskaya et al. (2020) studied this question.
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