Key result
Osteopontin expression tracks with calcification and macrophage accumulation in aortic stenosis.
Why the study?
Calcification in aortic valve stenosis may be actively regulated rather than a degenerative unmodifiable process, but the role of osteopontin in valvular lesions was unclear.
Population
14 human aortic valves ranging from normal to clinically stenotic
Design
Morphological and immunohistochemical observational study
Authors
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May implicate osteopontin in aortic stenosis progression; leaves open causal role and therapeutic potential.
Observational (n=14)
O’Brien et al. (1995) conducted an observational in Aortic stenosis (n=14). Osteopontin expression in 14 human aortic valves was significantly associated with the degrees of calcification and macrophage accumulation in early through late lesions of aortic stenosis.
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