Population
107 subjects, comprising 51 patients with calcific aortic valve disease and 56 controls. A subgroup of 27…
Design
Case-control
Authors
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May support OPN dephosphorylation as a CAVD biomarker; hypothesis-generating and requires prospective validation before clinical adoption.
Dephosphorylation of circulating osteopontin, specifically reduced phospho-threonine levels, correlates with severe valvular calcification and may serve as a biomarker for calcific aortic valve disease.
Sainger et al. (2011) studied this question.
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