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October 1, 1969Cardiovascular Research270 citations

Cardiovascular and Respiratory Changes During Sleep in Normal and Hypertensive Subjects

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JBJames BristowAHA. J. HonourTPThomas G. Pickering

Key Result

Sleep induces similar hemodynamic changes driven by diminished peripheral resistance in normal and hypertensive subjects, though hypertensives maintain decreased baroreflex sensitivity.

Structured PICO

How do haemodynamic parameters change during sleep in normal and hypertensive subjects?

P
Population
Normal subjects and subjects with raised arterial pressure (hypertension)
I
Intervention
Sleep
C
Comparator
Awake state
O
Outcome
Haemodynamic changes (blood pressure, peripheral resistance, baroreflex sensitivity)surrogate

The fall in blood pressure during sleep is driven by diminished peripheral resistance, with similar haemodynamic changes in normal and hypertensive subjects, though hypertensives have decreased baroreflex sensitivity.

Abstract

The fall of blood pressure accompanying sleep in man is largely due to a diminished peripheral resistance. Subjects with normal and raised arterial pressure show qualitatively and quantitatively similar haemodynamic changes during sleep, except that the baroreflex sensitivity in hypertensives is decreased, both awake and asleep.

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Cite This Study

Bristow et al. (1969) studied this question. Sleep induces similar hemodynamic changes driven by diminished peripheral resistance in normal and hypertensive subjects, though hypertensives maintain decreased baroreflex sensitivity.

synapsesocial.com/papers/6a0941df41a1eeaa06459160https://doi.org/10.1093/cvr/3.4.476
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An update on: cardiovascular and respiratory changes during sleep in normal and hypertensive subjects2000 · 53 citations
  2. 2Sleep-related changes in hemodynamic and autonomic regulation in human hypertension2009 · 32 citations
  3. 3SLEEP AND BLOOD PRESSURE1976 · 9 citations
  4. 4Reflex Regulation of Arterial Pressure during Sleep in Man1969 · 1,286 citations
  5. 5PHYSIOLOGICAL SLEEP‐DEPENDENT CHANGES IN ARTERIAL BLOOD PRESSURE: CENTRAL AUTONOMIC COMMANDS AND BAROREFLEX CONTROL2008 · 96 citations