Blood Pressure Lowering for Primary and Secondary Prevention of Stroke
Key result
Blood pressure is a powerful predictor of stroke, with a systolic blood pressure of 115 mm Hg explaining 60% of the population-attributable risk of stroke.
Why the study?
Does blood pressure lowering prevent stroke in individuals at risk for primary or secondary stroke?
Population
Individuals at risk for primary or secondary stroke
Design
Review
Authors
Discussion
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Member takes
Implication
Strengthens rationale for BP control in stroke prevention; leaves open optimal targets below 115 mm Hg.
Key Points
- To review the epidemiological literature assessing the lethal yet reversible relationship between elevated blood pressure and stroke incidence.
- Synthesized recent literature and epidemiological findings on global hypertension prevalence and stroke mortality.
- Evaluated population-attributable risks and lifetime incidence estimates, including data from the Framingham cohort and the World Health Organization.
- Systolic blood pressure above 115 mm Hg accounts for 60% of the population-attributable risk of stroke.
- Worldwide, 15 million people suffer a stroke each year, causing 5 million deaths and leaving 5 million individuals permanently disabled, with two thirds of fatalities occurring in developing nations.
Structured PICO
Does blood pressure lowering prevent stroke in individuals at risk for primary or secondary stroke?
P
Population
Individuals at risk for primary or secondary stroke
I
Intervention
Blood pressure lowering
O
Outcome
Strokehard clinical
Blood pressure lowering is a critical, reversible intervention for the primary and secondary prevention of stroke.
Cite This Study
Zhang et al. (2006) conducted a review in Stroke and Hypertension. Blood pressure lowering was evaluated. Blood pressure is a powerful predictor of stroke, with a systolic blood pressure of 115 mm Hg explaining 60% of the population-attributable risk of stroke.