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January 2, 1978JAMA

Thiazide-induced hypokalemia. Association with acute myocardial infarction and ventricular fibrillation

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Key result

Hypokalemia was present in 87% of patients receiving thiazides during acute myocardial infarction and ventricular fibrillation, compared to 2.6% of patients not receiving these medications.

Why the study?

Is thiazide use associated with hypokalemia in patients with acute myocardial infarction and ventricular fibrillation?

Population

59 patients with acute myocardial infarction and ventricular fibrillation

Comparison

Thiazide preparation vs Not receiving thiazide medications

Design

Cohort

Authors

MDM. DukeINTEGRIS Baptist Medical Center

Discussion

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Implication

Supports potassium monitoring in thiazide-treated acute MI; leaves open whether repletion reduces VF risk.

Study Design

Type

Observational (n=59)

Structured PICO

Is thiazide use associated with hypokalemia in patients with acute myocardial infarction and ventricular fibrillation?

P
Population
59 patients with acute myocardial infarction and ventricular fibrillation
I
Intervention
Thiazide preparation
C
Comparator
Not receiving thiazide medications
O
Outcome
Presence of hypokalemiasurrogate

Main Result

Absolute Event Rate: 87% vs 2.6%

Thiazide use is strongly associated with hypokalemia in patients presenting with acute myocardial infarction and ventricular fibrillation, highlighting the need for prompt potassium correction to mitigate arrhythmia risk.

Cite This Study

M. Duke (1978) conducted an observational in Acute myocardial infarction and ventricular fibrillation (n=59). Thiazide preparation vs. Not receiving thiazides was evaluated on Hypokalemia. Hypokalemia was present in 87% of patients receiving thiazides during acute myocardial infarction and ventricular fibrillation, compared to 2.6% of patients not receiving these medications.

synapsesocial.com/papers/6a094f72b0d552aa8b459b10https://doi.org/10.1001/jama.239.1.43

Topics

Hypertension management
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Also Consider

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  1. 1Effect of high K, low K, and quinidine on QRS duration and ventricular action potential1962 · 107 citations
  2. 2Relation of Electrolyte Disturbances to Cardiac Arrhythmias1973 · 279 citations
  3. 3Increase of Ventricular Excitability Threshold by Hyperpotassemia1965 · 49 citations
  4. 4Decrease in Serum Potassium Concentrations and Appearance of Cardiac Arrhythmias during Infusion of Potassium with Glucose in Potassium-Depleted Patients1962 · 89 citations