Key result
Baseline risk factors including male sex, older age, diabetes, and cardiovascular disease significantly increased the residual risk of cardiovascular events (RR 1.41-1.86) despite BP control.
Why the study?
What is the effect of individual baseline risk factors on the residual risk of cardiovascular events in treated Chinese hypertensive patients?
Population
9711 Chinese hypertensive patients
Comparison
More intense antihypertensive treatment vs Less intense antihypertensive treatment
Design
Cohort, randomized
Follow-up
40 months
Authors
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Residual CV risk stratification may inform closer monitoring in controlled hypertension; leaves open whether modifying these factors improves outcomes.
RCT (n=9,711)
What is the effect of individual baseline risk factors on the residual risk of cardiovascular events in treated Chinese hypertensive patients?
Effect estimate: RR 1.41-1.86
In Chinese hypertensive patients, traditional risk factors like male sex, older age, diabetes, and prior CVD increase residual cardiovascular risk despite effective BP reduction, whereas high cholesterol did not.
Zhang et al. (2010) conducted an RCT in Hypertension (n=9,711). More intense antihypertensive treatment vs. Less intense antihypertensive treatment was evaluated on Cardiovascular events (RR 1.41-1.86). Baseline risk factors including male sex, older age, diabetes, and cardiovascular disease significantly increased the residual risk of cardiovascular events (RR 1.41-1.86) despite BP control.
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