Key result
Higher SBP linked to ~34% greater CHD and stroke risk across all cholesterol levels.
Why the study?
What are the joint effects of systolic blood pressure and serum cholesterol on the risk of cardiovascular disease in Asia-Pacific populations?
Population
380,216 participants from 29 cohorts in Asia (78% of total) and 7 cohorts from Australia and New Zealand
Design
Cohort
Follow-up
2,547,447 person-years of observation
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Supports integrated BP-lipid assessment in Asia-Pacific cohorts; extends prior observational data on interactions while leaving causal effects open.
Cohort (n=380,216)
Yes
What are the joint effects of systolic blood pressure and serum cholesterol on the risk of cardiovascular disease in Asia-Pacific populations?
Hazard Ratio: 1.34 (95% CI 1.3–1.37)
p-value: p=<=0.0001
In Asia-Pacific populations, increasing systolic blood pressure and cholesterol independently raise cardiovascular risk, with the relative impact of blood pressure on CHD and ischemic stroke being slightly steeper at lower cholesterol levels.
A 2005 study conducted a cohort in Cardiovascular disease (n=380,216). Systolic blood pressure and serum cholesterol vs. Lower levels was evaluated on Time until first coronary heart disease or stroke event (HR 1.34, 95% CI 1.30-1.37, p=<=0.0001). Higher systolic blood pressure was associated with increased risk of CHD and stroke across all cholesterol levels, though the risk gradient was steeper at lower cholesterol levels.
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