Key result
Attempting to achieve lower diastolic blood pressure targets instead of standard targets did not significantly change total mortality (RR 0.92; 95% CI 0.86-1.15).
Why the study?
Do lower BP targets (<= 135/85 mmHg) reduce mortality and morbidity compared to standard BP targets (<= 140-160/ 90-100 mmHg) in patients with elevated blood pressure?
Population
22,089 subjects with elevated blood pressure from 7 randomized controlled trials
Comparison
Lower blood pressure targets (<= 135/85 mmHg) vs Standard blood pressure targets
Design
Meta-analysis
Authors
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No mortality benefit from lower diastolic targets; reinforces standard goals and tempers pursuit of intensive control in trials.
Systematic Review (n=22,089)
Do lower BP targets (<= 135/85 mmHg) reduce mortality and morbidity compared to standard BP targets (<= 140-160/ 90-100 mmHg) in patients with elevated blood pressure?
Effect estimate: RR 0.92 (95% CI 0.86-1.15)
Treating patients to lower than standard BP targets (<=135/85 mmHg) does not reduce mortality or morbidity compared to standard targets (<=140-160/90-100 mmHg).
Arguedas et al. (2009) conducted a systematic review in Hypertension (n=22,089). Lower blood pressure targets (<= 135/85 mmHg) vs. Standard blood pressure targets (<= 140-160/ 90-100 mmHg) was evaluated on Total mortality (RR 0.92, 95% CI 0.86-1.15). Attempting to achieve lower diastolic blood pressure targets instead of standard targets did not significantly change total mortality (RR 0.92; 95% CI 0.86-1.15).
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