What is the clinical evidence from this study?

Study design: Observational. Population: obstructive hypertrophic cardiomyopathy (n=1275). Intervention: Alcohol septal ablation. Primary outcome: all-cause mortality.

What does this research mean for the field?

Alcohol septal ablation provides durable symptom relief, significant reduction in left ventricular outflow tract obstruction, and low peri-procedural and long-term mortality in highly symptomatic patients with obstructive hypertrophic cardiomyopathy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to evaluate the long-term clinical outcomes following alcohol septal ablation in obstructive hypertrophic cardiomyopathy patients.

January 7, 2016European Heart JournalOpen Access

Long-term clinical outcome after alcohol septal ablation for obstructive hypertrophic cardiomyopathy: results from the Euro-ASA registry

Q: What are the key findings of this study?

Alcohol septal ablation in highly symptomatic patients with obstructive HCM demonstrated a 10-year survival rate of 77% (95% CI 73-80%) and reduced the LV outflow tract gradient (P<0.01).

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Key result

Alcohol septal ablation in obstructive HCM shows ~77% ten-year survival and lower LVOT gradients.

n=1,275

Why the study?

Does alcohol septal ablation improve long-term survival and symptoms in highly symptomatic patients with obstructive hypertrophic cardiomyopathy?

Population

1,275 highly symptomatic patients with obstructive hypertrophic cardiomyopathy, mean age 58 ± 14 years…

Design

Cohort

Follow-up

median 5.7 years

Authors

JVJosef VeselkaHeart Failure / Cardiomyopathy MJMorten K. JensenInterventional Cardiology MLMax LiebregtsInterventional Cardiology

Discussion

Member takes

Implication

Supports alcohol septal ablation for symptomatic obstructive HCM; extends registries but leaves open randomized comparison to myectomy.

Key Points

This research aims to evaluate the long-term clinical outcomes following alcohol septal ablation in obstructive hypertrophic cardiomyopathy patients.
Data from the Euro-ASA registry was analyzed, including 1275 symptomatic patients treated with ASA.
Patients had a median follow-up of 5.7 years, assessing mortality and NYHA class changes.
Multivariable analysis identified independent predictors of all-cause mortality.
30-day post-ASA mortality was 1%, with an overall mortality rate of 2.42 deaths per 100 patient-years during follow-up.
Survival rates were 98% at 1 year, 89% at 5 years, and 77% at 10 years after ASA.
Alcohol septal ablation significantly reduced NYHA class and LV outflow tract gradient (P < 0.01).

Study Design

Type

Observational (n=1,275)

Multicenter

Yes

Structured PICO

Does alcohol septal ablation improve long-term survival and symptoms in highly symptomatic patients with obstructive hypertrophic cardiomyopathy?

Population

1,275 highly symptomatic patients with obstructive hypertrophic cardiomyopathy (HCM), mean age 58 ± 14 years, multinational (Euro-ASA registry).

Intervention

Alcohol septal ablation (ASA)

Outcome

Long-term survival (all-cause mortality)hard clinical

Alcohol septal ablation provides durable symptom relief, reduction in LV outflow tract obstruction, and low long-term mortality in highly symptomatic patients with obstructive HCM.

Cite This Study

Veselka et al. (2016) conducted an observational in obstructive hypertrophic cardiomyopathy (n=1,275). Alcohol septal ablation was evaluated on all-cause mortality. Alcohol septal ablation in highly symptomatic patients with obstructive HCM demonstrated a 10-year survival rate of 77% (95% CI 73-80%) and reduced the LV outflow tract gradient (P<0.01).

synapsesocial.com/papers/6a0951c316dfdfe7ed33fe35 https://doi.org/10.1093/eurheartj/ehv693

Topics

Hypertrophic cardiomyopathy

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Long-term clinical outcome after alcohol septal ablation for obstructive hypertrophic cardiomyopathy: results from the Euro-ASA registry

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Long-term clinical outcome after alcohol septal ablation for obstructive hypertrophic cardiomyopathy: results from the Euro-ASA registry

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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