Photocontrollable Electrochemical Molecular Probe for the Detection of Cu ²⁺ in Brain Dialysates of Alzheimer’s Disease Mice

Hui Dong; Le Zhao; Guizhen Guo; Aixin Chang; Menghao Cheng; Yujia Qian; Liuyang Hu; Jiaxin Zhou; Yidan Ye; Yanli Zhou; Yajing Ma; Zhaohui Li; Maotian Xu

doi:10.1021/acssensors.6c00637

May 14, 2026ACS Sensors

Photocontrollable Electrochemical Molecular Probe for the Detection of Cu ²⁺ in Brain Dialysates of Alzheimer’s Disease Mice

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Key Points

This research aims to design a novel electrochemical probe to detect copper ions in the brain, specifically relating to Alzheimer's disease.
Developed a photocontrollable electrochemical molecular probe.
Utilized brain dialysates from Alzheimer's disease mouse models for testing.
Achieved effective detection of Cu2+ ions in brain dialysates.
Provided a new strategy for early diagnosis of Alzheimer's disease.

Implication

Demonstrates detection of copper ions in brain dialysates, suggesting early diagnosis of Alzheimer's disease.

Abstract

-mediated pathological processes in AD. It also offers a novel design strategy for the development of photocontrollable electrochemical probes for the early diagnosis of AD and other metal ion-related neurodegenerative diseases.

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Cite This Study

Dong et al. (2026) studied this question.

synapsesocial.com/papers/6a095a877880e6d24efe0791 https://doi.org/10.1021/acssensors.6c00637

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Photocontrollable Electrochemical Molecular Probe for the Detection of Cu ²⁺ in Brain Dialysates of Alzheimer’s Disease Mice

Key Points

Implication

Abstract

Discussion

Cite This Study

Photocontrollable Electrochemical Molecular Probe for the Detection of Cu ²⁺ in Brain Dialysates of Alzheimer’s Disease Mice

Key Points

Implication

Abstract

Discussion

Cite This Study

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