Dual-Mode Turn-On Fluorescent and Ratiometric Electrochemical Detection of Cu 2 + in Alzheimer’s Disease Mouse Brains Based on a Single Resorufin–Picolinate Probe

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This research aims to explore a new method for detecting copper ions in mouse brains affected by Alzheimer's disease using a specific probe.
Utilized a single resorufin–picolinate probe for detection.
Combined fluorescent and ratiometric electrochemical techniques for measuring copper ion levels.
Conducted tests in mouse models of Alzheimer's disease.
Successful dual-mode detection of Cu2+ ions in the brain tissue.
Demonstrated statistically significant increases in detection sensitivity compared to previous methods.
Provided evidence for potential clinical applications in diagnosing Alzheimer's disease.

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Demonstrates dual-mode detection of copper ions in Alzheimer's disease mice, indicating diagnostic potential.

dyshomeostasis and holds great potential for clinical translational applications in AD diagnosis.

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Dong et al. (2026) studied this question.

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