Epidural analgesia with ultra low-dose bupivacaine, epinephrine, and fentanyl or fentanyl alone allowed approximately 70% of women to ambulate safely during labor (68% vs 70%).
RCT (n=130)
Double-blind
Randomized
Absolute Event Rate: 68% vs 70%
The effectiveness of two epidural analgesic regimens on the ability to ambulate was compared in women in labor by a prospective, randomized, double-blind design. One group of patients received epidural fentanyl, a 75-micrograms bolus and an infusion of fentanyl 2.5 micrograms/mL at 15 mL/h (FENT, n = 53). A second group received ultra low-dose bupivacaine (0.04%), epinephrine (1.7 micrograms/mL), and fentanyl (1.7 micrograms/mL) (BEF, n = 77), a 15-mL bolus followed by an infusion at 15 mL/h. Adequate analgesia was rapidly obtained in 90.6% of patients in the FENT group and 92.2% of patients in the BEF group (P = 0.89). Seventy percent of patients in the FENT group ambulated versus 68% in the other group. The BEF mixture provided analgesia of longer duration (287 +/- 171 min versus 156 +/- 72 min, P = 0.0001). The number of patients delivering during administration of only their study drug (without needing higher doses of local anesthetics) was 52% for BEF and 21% for FENT (P = 0.0005). Hip flexion weakness precluding ambulation occurred in 17% (P = 0.002) of BEF patients and orthostatic hypotension in 9% (P = 0.08). Neither problem occurred in FENT patients. Neonatal outcome was similar in both groups. Approximately 70% of women receiving epidural analgesia with fentanyl or ultra low-dose bupivacaine, epinephrine, and fentanyl may ambulate safely during labor.
Breen et al. (Mon,) conducted a rct in Labor (n=130). Ultra low-dose bupivacaine, epinephrine, and fentanyl (BEF) vs. Epidural fentanyl (75-μg bolus and 2.5 μg/mL infusion at 15 mL/h) was evaluated on Ability to ambulate. Epidural analgesia with ultra low-dose bupivacaine, epinephrine, and fentanyl or fentanyl alone allowed approximately 70% of women to ambulate safely during labor (68% vs 70%).