Why the study?
Does the addition of epinephrine to epidural bupivacaine and fentanyl increase the duration of analgesia in healthy parturients during labor?
Population
150 healthy parturients (100 in part 1, 50 in part 2) undergoing epidural analgesia during labor
Comparison
Part 1: 10 ml of 0.25% bupivacaine with 5… vs Part 1: 10 ml of 0.25% bupivacaine with 5…
Design
RCT, random manner
Follow-up
Duration of labor
Authors
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Supports epinephrine addition to labor epidurals for prolonged analgesia; confirms 2-chloroprocaine test-dose attenuation in RCTs.
Does the addition of epinephrine to epidural bupivacaine and fentanyl increase the duration of analgesia in healthy parturients during labor?
Adding epinephrine to epidural bupivacaine and fentanyl prolongs labor analgesia, though this effect is attenuated by prior use of a 2-chloroprocaine test dose.
Grice et al. (1990) studied this question.
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