What question did this study set out to answer?

To explore the relationship between BMI, inflammation, and cognitive performance in bipolar disorder and healthy controls, and to assess if inflammation mediates this relationship.

May 17, 2026Bipolar Disorders

Association Between Elevated Body Mass Index, Inflammation, and Cognitive Performance in Individuals With Bipolar Disorder and Healthy Controls

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To explore the relationship between BMI, inflammation, and cognitive performance in bipolar disorder and healthy controls, and to assess if inflammation mediates this relationship.
127 participants (79 bipolar disorder, 48 healthy controls) completed the MATRICS Consensus Cognitive Battery.
Blood levels of C-reactive protein, interleukin-6, and tumor necrosis factor were measured, and a composite inflammation index was created.
Regression and mediation analyses were conducted using SAS software.
Bipolar disorder individuals exhibited significantly higher inflammation than healthy controls (p < 0.05).
Increased BMI correlated with poorer cognitive performance in the total sample (beta = -0.22, p = 0.006).
IL-6 was found to partially mediate the BMI-cognition link (ab: beta = -0.09, CI = -0.18, -0.01).

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Implication

Randomized trial investigates cognitive impacts of BMI and inflammation in bipolar disorder and healthy controls, suggesting IL-6's mediating role.

Cite This Study

Majd et al. (2026) studied this question.

synapsesocial.com/papers/6a095bba7880e6d24efe1936 https://doi.org/10.1111/bdi.70111

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Implication

Randomized trial investigates cognitive impacts of BMI and inflammation in bipolar disorder and healthy controls, suggesting IL-6's mediating role.

Association Between Elevated Body Mass Index, Inflammation, and Cognitive Performance in Individuals With Bipolar Disorder and Healthy Controls

Key Points

Discussion

Implication

Cite This Study

Association Between Elevated Body Mass Index, Inflammation, and Cognitive Performance in Individuals With Bipolar Disorder and Healthy Controls

Key Points

Discussion

Implication

Cite This Study

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