Key result
Bipolar disorder and anxiety linked to elevated inflammatory and cardiac biomarkers versus healthy controls.
Why the study?
Mental disorders are frequently associated with metabolic, inflammatory, and behavioral alterations that increase physical comorbidity risk, but their inflammatory, metabolic, and cardiac biomarker profiles needed characterization.
Are mental disorders associated with distinct inflammatory, metabolic, and cardiac biomarker profiles compared to healthy controls?
Cross-Sectional (n=50)
Yes
Are mental disorders associated with distinct inflammatory, metabolic, and cardiac biomarker profiles compared to healthy controls?
Mental disorders are associated with distinct metabolic and inflammatory biomarker profiles, including elevated CRP and IL-6 in anxiety and bipolar disorder, and reduced vitamin D in depression.
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These cross-sectional associations should not yet change practice; leaves open causal cardiovascular links requiring longitudinal confirmation.
Godoy et al. (2026) conducted a cross-sectional in Adults with diagnosed anxiety, depression, or bipolar disorder without comorbid metabolic or autoimmune disorders under pharmacological treatment (n=50). Patients with bipolar disorder showed significantly higher CK-MB (p=0.0325), CRP (p<0.0001), IL-6 (p=0.0198), and IL-1β (p=0.0067) levels; anxiety group had elevated CRP (p=0.0038), hs-CRP (p=0.0048), and IL-6 (p=0.0030); depression group had reduced vitamin D (p=0.0302) compared to controls.
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