Key result
In inpatients with major depression, the presence of metabolic syndrome significantly affected levels of adiponectin (P<0.05) and IL-6 (P<0.05), with a trend for fibrinogen (P=0.06).
Why the study?
Does the presence of metabolic syndrome alter inflammatory biomarker levels in inpatients with major depressive disorder?
Population
70 inpatients with major depressive disorder, with or without the metabolic syndrome
Comparison
Presence of metabolic syndrome vs Absence of metabolic syndrome
Design
Cross-sectional
Follow-up
4 to 5 weeks after admission
Authors
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May indicate additive inflammatory burden in depressed inpatients with metabolic syndrome; hypothesis-generating, prospective studies needed.
Cross-Sectional (n=70)
No
Does the presence of metabolic syndrome alter inflammatory biomarker levels in inpatients with major depressive disorder?
p-value: p=<.05
The presence of metabolic syndrome in patients with major depression is associated with altered levels of specific inflammatory biomarkers (adiponectin and IL-6), suggesting an additive inflammatory burden.
Zeugmann et al. (2010) conducted a cross-sectional in Major depressive disorder (n=70). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Concentrations of inflammatory biomarkers (p=<.05). In inpatients with major depression, the presence of metabolic syndrome significantly affected levels of adiponectin (P<0.05) and IL-6 (P<0.05), with a trend for fibrinogen (P=0.06).
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