Why the study?
Are there differences in serum inflammatory mediators and HPA axis activity among patients with major depressive disorder with or without metabolic syndrome compared to healthy controls?
Are there differences in serum inflammatory mediators and HPA axis activity among patients with major depressive disorder with or without metabolic syndrome compared to healthy controls?
Neuroendocrine and inflammatory factors, such as cortisol, CRP, and IL-6, are elevated in major depressive disorder and may play a role in the pathogenesis of depression and metabolic syndrome.
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Elevated inflammatory markers in MDD ± MS warrant mechanistic studies; leaves open whether they guide risk stratification or therapy.
Martinac et al. (2017) studied this question.
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