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This study aims to characterize metabolic hormone and adipokine profiles in patients with major depressive disorder and their association with depression severity and early-life adversity.

May 29, 2026Communications MedicineOpen Access

Metabolic hormone and adipokine alterations in major depressive disorder in relation to the acute-phase inflammatory response and early-life adversity

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TCTangcong ChenUniversity of Electronic Science and Technology of China YLYueyang LuoUniversity of Electronic Science and Technology of China MNMengqi NiuUniversity of Electronic Science and Technology of China

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Randomized trial examines metabolic hormones' role in depression severity and early-life adversity in patients.

Key Points

This study aims to characterize metabolic hormone and adipokine profiles in patients with major depressive disorder and their association with depression severity and early-life adversity.
Characterized metabolic hormone and adipokine profiles in 125 MDD inpatients and 40 healthy controls.
Measured fasting serum levels of hormonal markers and assessed acute-phase inflammatory response.
Utilized correlation, regression analyses, and ROC-AUC to evaluate associations and discriminative performance.
MDD patients demonstrated significantly lower insulin, glucagon, and PAI-1 levels compared to controls.
A composite GAP index correlated negatively with depression severity, suicidal ideation, and adverse childhood experiences.
A model combining GAP index, inflammatory markers, and childhood adversity achieved an AUC of 0.864, indicating 80% accuracy in distinguishing MDD from controls.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a192cd5fab5b468c4415a13 https://doi.org/10.1038/s43856-026-01686-4

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Metabolic hormone and adipokine alterations in major depressive disorder in relation to the acute-phase inflammatory response and early-life adversity

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Cite This Study

Metabolic hormone and adipokine alterations in major depressive disorder in relation to the acute-phase inflammatory response and early-life adversity

Discussion

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Implication

Key Points

Cite This Study

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