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This review aims to clarify how cannabinoids affect microglial and astrocytic functions in relation to neuroinflammation.

Effects of phytocannabinoids, synthetic and semi-synthetic cannabinoids on microglia and astrocytes: Review of neuroinflammatory mechanisms

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This review aims to clarify how cannabinoids affect microglial and astrocytic functions in relation to neuroinflammation.
Systematic review following JBI and PRISMA-ScR guidelines.
Evidence sourced from PubMed, Scopus, and Web of Science.
Thematically organized and qualitatively summarized findings.
Acute cannabinoid exposure appears neuroprotective; effects of chronic exposure remain unclear.
Preliminary findings suggest synthetic cannabinoids may retain protective actions.
Delta-9-tetrahydrocannabinol (THC) may promote glial activation and neuroinflammation.

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Review discusses cannabinoid impacts on microglia and astrocytes in neuroinflammation, highlighting therapeutic potential.

Brambilla et al. (2026) studied this question.

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