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This study investigates how cannabis-derived compounds affect calcium signaling in human and mouse microglia, focusing on inflammation.

Calcium signaling in human and mouse microglia exhibit differential susceptibility to phytocannabinoids

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This study investigates how cannabis-derived compounds affect calcium signaling in human and mouse microglia, focusing on inflammation.
Examined 22 cannabis-derived compounds using pharmacological modulators and live-cell calcium imaging.
Analyzed cytokine and nitric oxide release in human (HMC3) and mouse (BV2) microglial models.
Characterized store-operated calcium entry and purinergic signaling dynamics under resting and activated conditions.
Minor acidic cannabinoids (CBGA, CBGVA, CBDVA) strongly inhibited store-operated calcium entry in both microglial models.
Only mouse microglial (BV2) inflammatory responses were significantly reduced by several cannabinoids (e.g., CBD, CBG, CBDVA).
Human microglia (HMC3) showed limited purinergic responses and did not exhibit reduced cytokine release despite calcium signaling alterations.

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Randomized trial examines calcium signaling alterations in microglia by phytocannabinoids, suggesting distinct inflammatory responses across models.

Pilchová et al. (2026) studied this question.

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Randomized trial examines calcium signaling alterations in microglia by phytocannabinoids, suggesting distinct inflammatory responses across models.