Chronic Kidney Disease, Time in Therapeutic Range and Adverse Clinical Outcomes in Anticoagulated Patients with Non-valvular Atrial Fibrillation: Observations from the SPORTIF Trials
Key result
CKD in AF predicts stroke and death while TTR >70% is linked to lower risk.
- P=0.006 for stroke, <0.001 for death
- n=3,646
Why the study?
Does chronic kidney disease and time in therapeutic range impact the risk of stroke, death, and major bleeding in anticoagulated patients with non-valvular atrial fibrillation?
Population
3646 patients with non-valvular atrial fibrillation assigned to warfarin with data on renal function from…
Comparison
Chronic kidney disease and time in therapeutic… vs Normal renal function and TTR <70%
Design
Cohort
Authors
Discussion
Loading...
Member takes
Implication
CKD signals higher stroke and mortality risk on warfarin in AF; extends TTR evidence but should not yet change practice.
Study Design
Type
Observational (n=3,646)
Multicenter
Yes
Structured PICO
Does chronic kidney disease and time in therapeutic range impact the risk of stroke, death, and major bleeding in anticoagulated patients with non-valvular atrial fibrillation?
P
Population
3646 patients with non-valvular atrial fibrillation assigned to warfarin with data on renal function from the SPORTIF III and V trials
I
Intervention
Chronic kidney disease (creatinine clearance <60ml/min) and time in therapeutic range (TTR) >70%
C
Comparator
Normal renal function and TTR <70%
O
Outcome
Stroke and deathhard clinical
Main Result
p-value: p=0.006 for stroke, <0.001 for death
In AF patients on warfarin, CKD is highly prevalent and predicts stroke and death, while maintaining a TTR >70% independently reduces the risk of stroke, death, and major bleeding.
Cite This Study
Proietti et al. (2016) conducted an observational in Non-valvular Atrial Fibrillation (n=3,646). Warfarin was evaluated on Stroke, death, and major bleeding (p=0.006 for stroke, <0.001 for death). Chronic kidney disease in atrial fibrillation patients independently predicted stroke (p=0.006) and death (p<0.001), while TTR >70% predicted lower risks of stroke, death, and major bleeding.