What question did this study set out to answer?

To evaluate the role of monocyte- and macrophage-activating cytokines in the pathogenesis of haemophagocytic lymphohistiocytosis in adult patients.

June 1, 1994British Journal of Haematology

Involvement of interferon‐γ and macrophage colony‐stimulating factor in pathogenesis of haemophagocytic lymphohistiocytosis in adults

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To evaluate the role of monocyte- and macrophage-activating cytokines in the pathogenesis of haemophagocytic lymphohistiocytosis in adult patients.
Measured serum cytokine concentrations in 21 adult patients during active haemophagocytic lymphohistiocytosis and during disease remission.
Assessed spontaneous in vitro production of cytokines from isolated circulating CD2+ T-cells and monocytes.
Serum levels of M-CSF, IFN-gamma, IL-6, TNF-alpha, soluble CD8, and soluble IL-2 receptor were markedly elevated during active disease and normalized during remission.
Neither IL-4 nor GM-CSF was detectable in the sera of patients with active disease.
Cultured circulating CD2+ T-cells spontaneously secreted M-CSF and IFN-gamma, whereas monocytes produced high levels of IL-6 and TNF-alpha without detectable M-CSF or IFN-gamma.

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Implication

Observational study reveals elevated interferon-gamma and macrophage colony-stimulating factor in adult HLH, indicating T-cell-driven monocyte activation.

Cite This Study

Akashi et al. (1994) studied this question.

synapsesocial.com/papers/6a09625830285ee4a133fa41 https://doi.org/10.1111/j.1365-2141.1994.tb04905.x

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Implication

Observational study reveals elevated interferon-gamma and macrophage colony-stimulating factor in adult HLH, indicating T-cell-driven monocyte activation.

Involvement of interferon‐γ and macrophage colony‐stimulating factor in pathogenesis of haemophagocytic lymphohistiocytosis in adults

Key Points

Discussion

Implication

Cite This Study

Involvement of interferon‐γ and macrophage colony‐stimulating factor in pathogenesis of haemophagocytic lymphohistiocytosis in adults

Key Points

Discussion

Implication

Cite This Study

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