Key result
Hypertension in impaired glucose tolerance is linked to incident diabetes and ~35% higher cardiovascular risk.
Why the study?
Hypertension is more prevalent in individuals with impaired glucose tolerance, but whether higher blood pressure per se or mild hyperglycemia combined with hypertension enhances CVD risk remained unclear.
Does hypertension increase the long-term risk of diabetes and cardiovascular events in individuals with impaired glucose tolerance?
Cohort (n=568)
Does hypertension increase the long-term risk of diabetes and cardiovascular events in individuals with impaired glucose tolerance?
Effect estimate: HR 1.35 (95% CI 1.01-1.81)
Absolute Event Rate: 27.7% vs 16.6%
p-value: p=0.04
In individuals with impaired glucose tolerance, comorbid hypertension significantly increases the long-term risk of developing both diabetes and cardiovascular events.
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Hypertension may confer elevated long-term diabetes and CV risks in impaired glucose tolerance; leaves open whether intervention alters outcomes.
Li et al. (2018) conducted a cohort in Impaired glucose tolerance (n=568). Hypertension vs. No hypertension was evaluated on Incidence of cardiovascular events (HR 1.35, 95% CI 1.01-1.81, p=0.04). Hypertension in individuals with impaired glucose tolerance increased the 23-year risk of developing diabetes (HR 1.26; 95% CI 1.04-1.54) and cardiovascular events (HR 1.35; 95% CI 1.01-1.81).
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