Key result
Macro-CK type 2 in metastatic prostate cancer highlights a diagnostic pitfall in interpreting CK-MB elevations.
Case Report (n=1)
Highlights the importance of recognizing macro-CK type 2 as a diagnostic pitfall when interpreting CK-MB elevations to differentiate cardiac from non-cardiac origins.
Recognizing macro-CK type 2 avoids misdiagnosing cardiac injury in cancer patients; this case leaves open broader testing recommendations.
The isoenzyme creatine kinase muscle/brain (CK-MB) still plays an important role for the differential diagnosis of CK elevations and the clarification of their origin from heart or skeletal muscle. Therefore, it is necessary to know the diagnostic pitfalls in interpreting CK-MB results. We demonstrate a case of macro-CK type 2 in a 75-year-old patient with metastatic castration-resistant prostate cancer and its identification by isoenzyme electrophoresis, which can be typical for cancer diseases.
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Eidizadeh et al. (2018) conducted a case report in metastatic castration-resistant prostate cancer (n=1). isoenzyme electrophoresis was evaluated on identification of macro-CK type 2. Isoenzyme electrophoresis identified macro-CK type 2 in a 75-year-old patient with metastatic prostate cancer, highlighting a diagnostic pitfall in interpreting CK-MB elevations.
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