Key result
Elevated serum creatine kinase-BB fraction in patients with metastatic prostate carcinoma can be mistakenly read as creatine kinase-MB by some automated laboratory techniques, mimicking myocardial infarction.
Case Report (n=1)
Elevated creatine kinase-BB in metastatic prostate cancer can cause false-positive CK-MB results on automated assays, potentially leading to misdiagnosis of acute myocardial infarction.
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Alerts clinicians to CK-BB assay interference in metastatic prostate cancer; case report leaves open broader diagnostic impact.
The measurement of creatine kinase isoenzymes, particularly the MB fraction, is a major determinant for acute myocardial infarction. Patients with metastatic carcinoma of the prostate may have an elevated serum creatine kinase-BB fraction, which by some automated laboratory techniques may be read mistakenly as creatine kinase-MB. We report such a case and discuss the creatine kinase isoenzyme measurement.
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Stein et al. (1984) conducted a case report in Metastatic carcinoma of the prostate (n=1). Automated laboratory techniques for creatine kinase isoenzyme measurement was evaluated on Mistaken reading of creatine kinase-BB fraction as creatine kinase-MB. Elevated serum creatine kinase-BB fraction in patients with metastatic prostate carcinoma can be mistakenly read as creatine kinase-MB by some automated laboratory techniques, mimicking myocardial infarction.
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