Key result
Macromolecules caused a false-positive elevation of creatine kinase MB mass concentrations in a patient following nephrectomy for renal cell carcinoma.
Macromolecules can cause false-positive elevations in CK-MB mass concentration assays, potentially confounding the diagnosis of acute myocardial infarction.
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May confound post-nephrectomy CK-MB interpretation; leaves open assay interference prevalence and mitigation strategies.
Creatine kinase MB isoform (CK-MB) is a biochemical marker that is used to evaluate patients with suspected acute myocardial infarction. Rapid immunoassays to measure CK-MB mass concentration use various monoclonal anti-CK-MB antibodies, and these have been reported to be highly sensitive, specific, and free of interference
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Kim et al. (2014) studied this question. Macromolecules caused a false-positive elevation of creatine kinase MB mass concentrations in a patient following nephrectomy for renal cell carcinoma.
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