The research aims to develop a method for determining nucleic acid concentrations and their sequence homology in mixtures.
Introduced a dot hybridization procedure for analyzing nucleic acids.
Evaluated the method's ability to assess relative concentrations and homology.
Applied the method to both RNA and DNA species.
Successfully determined the relative concentrations of nucleic acids in mixtures.
Established sequence homology between related RNA and DNA species.
Abstract
A dot hybridization method is presented for rapidly determining the relative concentrations of nucleic acids in a mixture, as well as the extent of sequence homology between related RNA or DNA species.